rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo
IWR-1-endo
CAS: 1127442-82-3
Molecular Formula: C25H19N3O3
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo - Names and Identifiers
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo - Physico-chemical Properties
| Molecular Formula | C25H19N3O3 |
| Molar Mass | 409.44 |
| Density | 1.425±0.06 g/cm3(Predicted) |
| Boling Point | 643.9±55.0 °C(Predicted) |
| Specific Rotation(α) | -3.0～+3.0°(20℃/D)(c=0.1,CH3CN) |
| Solubility | Soluble in DMSO |
| Appearance | Liquid |
| Color | white to beige |
| pKa | 11.88±0.43(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Use | IWR-1 are end-anchor polymerase inhibitors that inhibit the Wnt/β-catenin signaling pathway. |
| In vitro study | IWR-1 and XAV939, as reversible inhibitors of the Wnt pathway, have similar pharmacological effects in vitro and in vivo, with IWR-1 acting through interaction with Axin, while XAV939 binds directly to TNKS. |
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo - Risk and Safety
| WGK Germany | 3 |
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.442 ml | 12.212 ml | 24.424 ml |
| 5 mM | 0.488 ml | 2.442 ml | 4.885 ml |
| 10 mM | 0.244 ml | 1.221 ml | 2.442 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.488 ml |
Last Update：2024-01-02 23:10:35
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo - Introduction
IWR-1-endo is a compound which is a white crystalline solid soluble in organic solvents. Its chemical name is ethyl 7-(4-(all-trans-4-hydroxycyclohexyl) phenyl) aspartate. IWR-1-endo is a small molecule inhibitor, which is mainly used to study and intervene in the protein degradation mechanism of cell signaling pathway, especially to regulate cell development and disease process by inhibiting the protein decomposition mechanism of Wnt signaling pathway.
The method of preparing IWR-1-endo is more complicated and generally needs to be obtained by chemical synthesis. Its synthesis path includes multiple steps, usually with aspartic acid and benzoic anhydride as raw materials, through esterification, substitution and reduction and other chemical reactions, and finally get the target product.
Need to pay attention to safety issues when using IWR-1-endo. It is a potentially toxic compound that is irritating to the eyes, skin and respiratory tract, so wear protective equipment and ensure good ventilation during handling and storage. In addition, it is necessary to operate under chemical laboratory conditions and comply with relevant safe operating procedures. More research and evaluation is needed on the long-term effects on human health and the environment.
The method of preparing IWR-1-endo is more complicated and generally needs to be obtained by chemical synthesis. Its synthesis path includes multiple steps, usually with aspartic acid and benzoic anhydride as raw materials, through esterification, substitution and reduction and other chemical reactions, and finally get the target product.
Need to pay attention to safety issues when using IWR-1-endo. It is a potentially toxic compound that is irritating to the eyes, skin and respiratory tract, so wear protective equipment and ensure good ventilation during handling and storage. In addition, it is necessary to operate under chemical laboratory conditions and comply with relevant safe operating procedures. More research and evaluation is needed on the long-term effects on human health and the environment.
Last Update：2024-04-09 20:52:54
![rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo](http://res.chembk.com/assets/images/structure/301071.gif)
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Spot supply
Product Name: IWR-1-endo Visit Supplier Webpage Request for quotationCAS: 1127442-82-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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